Ua hoʻokumu ʻia ka mālama o Nuevo León ma Monterrey a pili i ka Panalāʻau o Zacatecas. Ua hoʻohana ka Franciscans i kēia noho ʻana a komo i loko o ka ʻāina ʻo Neolonese a ma 1604 ua hoʻokumu ʻia ka mikiona mua ma lalo o ka inoa ʻo San Andrés.
Ua hoʻokumu ʻia ka mālama o Nuevo León ma Monterrey a pili i ka Panalāʻau o Zacatecas. Ua hoʻohana ka poʻe Franciscans i kēia noho ʻana a komo i loko o ka ʻāina ʻo New Leonese a ma 1604 ua hoʻokumu ʻia ka mikiona mua ma lalo o ka inoa ʻo San Andrés.
I ka hapa lua o ke kenekulia ʻumikūmāhā wale nō ʻehā mau mikiona i koe, ʻoiai i ka makahiki 1777 aneane pau lākou i kaomi ʻia a ua hoʻokumu ʻia kahi episekopo ma San Felipe Linares.
ʻO nā ʻaha kūkā mua ʻekolu i hoʻokumu ʻia ma Nuevo León e lawelawe i nā hale komo komo: San José de Río Blanco (Zaragoza), Valle del Peñón (Montemorelos) a me Cerralvo. ʻO ke koena o nā hale i pono e hana i kahi misionari e hoʻomākaukau i ka ʻoihana hana —San José de Cadereyta nona ke kumu kumu mai 1616 a me ka hoʻohui ʻia ʻana ma 1660—, Santa María de los Angeles del Río Blanco (Aramberri), San Cristóbal Hualahuises , Alamillo, San Nicolás de Agualeguas a me San Pablo de Labradores (Galeana).
ʻO kekahi o nā mikiona i mālama ʻia a hiki i kēia lā ʻo Santa María de los Dolores de la Punta de Lampazos. Aia ia ma ke kaona o Lampazos de Naranjo, ma ka Plaza de la Corregidora, a ʻo Fray Diego de Salazar ka mea i kūkulu ʻia, a ua kanu ʻia i ka makahiki 1720 ma ia wahi like. Ma Kēkēmapa 15, 1895, ua hoʻololi ʻia ka hale i ke Kula o nā Kaikamahine o ka Puʻuwai Hemolele o Iesū a mau aku a hiki i ka 1913. He mau makahiki ma hope ua noho ʻia e nā pūʻali koa pekelala ma lalo o ke alakaʻi a General Manuel Gómez a mai ka 1942 ua haʻalele ʻia ia, e ʻehaʻeha nei i ka hopena hōʻino.
Aia i ka luakini kahi hoʻolālā basilica a loaʻa i nā aʻe ākea e hoʻopuni ana i ka piko waena. Ua hoʻohana ʻia ke atrium ma ke ʻano he pantheon a he mau koena pena i ka frieze kona mau paia o loko.
Ua kūkulu ʻia he ʻaha hou he 12 Franciscan i nā kenekulia 16 a me 17. Ma 1782 ua manaʻo ʻia e kūkulu canonically i kēia Custody, e hui pū me ia o Parral, akā ʻaʻole hiki ke hana ʻia. Ua hoʻomau kekahi ʻāpana maikaʻi o kēia mau mikiona i kā lākou lawelawe ʻana a hiki i ka waena o ke kenekulia 19; Akā i ka makahiki 1860, ka makahiki o ka secularization kīwila o nā ʻaoʻao haipule, ua lilo lākou i mau pākaua a i ʻole nā kūlanakauhale pili i kēlā mau mea, ma lalo o ka mālama ʻana a nā kahunapule diocesan.
