ʻO Ignacio Comonfort, ke keiki a nā mākua Palani, ua hānau ʻia ma ka lā 12 Malaki 1812 ma Amozoc, Puebla a make ma Nowemapa 13, 1863.
Ua mālama ʻo ia i nā kūlana koʻikoʻi mai ka wā ʻōpio, ua alakaʻi ʻo ia i ka Customs Acapulco i ka makahiki 1854, e hōʻike ana iā ia iho he "ʻano" mākaukau i nā limahana. ʻO ia ka mea hoʻolaha nui o ka Plan Ayutla (1854), ka mea ʻike ʻole iā Santa Anna. Ua hoʻokumu ʻo ia i ka National Guards e kaua aku iā ia ma waena a me ka ʻākau o Mexico. I ʻOkakopa 1855 ua koho ʻia ʻo ia i pelekikena pani a ma hope iki i pelekikena kumukānāwai, kahi kūlana i mālama ʻia no kekahi mau mahina wale nō.
Ua haʻalele ʻia e kona mau pūʻali koa a ua hoʻohewa ʻia e nā liberal a me nā conservatives, ua hāʻawi ʻo ia i kahi kipi me ka hoʻohiki ʻana i ke Kumukanawai o 1857. I Ianuali 1858 ua haʻalele ʻo ia no Veracruz mai kahi i hoʻomaka ai no ka United States. Ua hoʻi ʻo ia i Mekiko ma ke noi a Benito Juárez e kaua aku i ka poʻe Palani a ua koho ʻia ʻo ia i pūkaua nui no ka pūʻali koa Mekiko. Ua make ʻo ia i kahi hoʻohālua kokoke iā Celaya (Gto.) I ka makahiki 1863.
