ʻO Macehual India mai Cuautitlán a ka Puʻupaʻa o Guadalupe i hōʻike ʻia ma ka puʻu ʻo Tepeyac i nā manawa ʻehā.
Manaʻo ʻia ua hānau ʻia ʻo Juan Diego i ka 1474 a i ka manawa o nā pale lole e noho ana ʻo ia ma Tulpetlac me kona ʻanakala ʻo Juan Bernardino, kahi a ka Guadalupana i hōʻike aku ai, e hoʻōla iā ia mai kahi maʻi koʻikoʻi. Ma mua o ka hana mana, ua nīnau aku ʻo Bishop Juan de Zumárraga iā Juan Diego no ka hōʻoia o nā hiʻohiʻona. Wahi a ka puke moʻolelo e pili ana i nā hanana o Tepeyac, ua kauoha ka Puʻupaʻa iā Juan Diego e ʻoki i kekahi mau rosa i pua nani wale i ka piko o ka puʻu a lawe iā lākou i Zumárraga i kāna ayate (serape de ixtle). ʻO ka moʻolelo e pili ana i ka manawa i hōʻike aku ai ʻo Juan Diego i ka pīhopa i nā pua, ua hōʻike kupanaha ʻia ke kiʻi o ka Virgin, i kapa ʻia ʻo Guadalupe e nā Paniolo, i paʻi ʻia ma ka ayate. Ua make ʻo Juan Diego i 1548.
